Trillions of bacteria live in your intestines, and influence your body on your homeostasis daily. Far from being limited to the limits of your digestive tract, your dynamic bowel is intricately linked to other body systems by a number of tracks complex, including the intestinal gut-brain axis and recently revealed the intestines-brain and bone marrow axis, the latter of which may affect blood pressure, more and more.
It has become increasingly clear that your brain, your immune system and your gut microbes are intimately linked, so it is not an extension to add bone marrow to the contacts list. Immune cells stem from bone marrow, bone marrow inflammation, which may result from high blood pressure, and are known to be caused by a signal of the brain. In a study published in the Frontier Journal of Physiology, researchers also revealed that the immune cells in the bone marrow play an important role in the signals between the brain and the intestines.
Bowel and Brain Detection and Bone Marrow Connection
In an animal study, the researchers replaced the natural bone marrow of mice with bone marrow cells from genetically engineered mice. The marrow has been modified to be incomplete in the receptors of the adrenal gland beta, making it less responsive to the messages of the brain.
"In this way," wrote the researchers in The Conversation, "we can investigate how the immune brain host communications will alter gut microbiota. In fact, by studying this new mouse model, we are determined to have our nervous system--managed by our brain-- can be modified of gut microba by communicating directly with the bone marrow immune cells. Brain, next, our gut microba can be changed indirectly by talking to the bone."
In short, when the bone marrow was less able to communicate with the brain, the "faint inflammatory response" was observed in the intestines, which in turn led to a more versatile (i.e. health) microbiome. The study shed light on one of the complex ways your bowel health may be involved in it from your heart and brain, with the researchers noting:
"In the context of cardiovascular diseases, this silent inflammatory response seems to be useful, as it reduces the interest of blood pressure in our experimental mice.
Interestingly, the relationship between gut microbiota and our mental health has recently become more pronounced. In particular, some suggested that intestinal microbiota affect stress and anxiety paths in the brain in a way mood and behaviour can change both positively and negatively, giving a whole new meaning to the term ' feeling of the intestines'."
Imbalanced Bowel Microbes Play a Role in High Blood Pressure
Imbalanced bowel microbes, known as bowel dysbiosis, have been linked in the former to heart disease and hypertension, but the recent animal study shed more light on the unique connection. The researchers gave the mice antibiotics for 10 days to eliminate their natural microbiota, and then planted the hypertensive microbiota hypertension in mice with normal blood pressure and rats with high blood pressure, in turn, were planted with normal microbiota plants.
The results were amazing in that highly compressed microbiota had developed high blood pressure, while the transplantation of natural microbiota led to only a slight decrease in blood pressure among high-pressure mice. "We conclude that the digestive disorders can affect directly SBP [systolic blood pressure]," wrote the researchers, Bio biomanipulation of microbiota, such as by using probiotic or eating fermented foods, maybe "innovative treatment for hypertension."
However, it's not the first time that such a link has been detected. The systematic review and meta-analysis of nine randomised and controlled studies found significant benefits for people suffering from hypertension, which consumes probiotic in products such as yogurt and milk. On average, compared to placebo, probiotic consumption reduction of systolic blood pressure (higher number) by 3.56 mm Hg and diastolic blood pressure (lower number) by 2.38 mm Hg.
It seems that at least 100 billion colony formation units of probiotic in the day were necessary to trigger these improvements, and was only seen taking advantage of those who consume probiotic for eight weeks or more. In 2015, at the same time, some intestinal microbes, which are divorced and bacterial bacteria, have been associated with increased blood pressure in mice.
"Nutrient fermentation products by gut microbiota can influence blood pressure through the regulation of energy spending, metabolism the intestines of the catecholamines, the gastrointestinal and renal diseases, and the sensitivity of salt," according to the research published in the journal Current Opinion in Nephrology and Hypertension.
Probiotic Found to Benefits Digestive Diseases, Mental Health
The addition of useful microbes has been found for the benefit of people struggling with serious bowel diseases, including necrotizing enterocolitis (NEC), which often occurs in preterm infants and can be fatal. The Australian study revealed that supplementary supplements to probiotic significantly reduced NEC of the risks and mortality in preterm infants, lowering incidence NEC at least 30% premature infant infection rate.
The probiotic was also found to take advantage of the irritabel bowel syndrome (IBS), which is often seen in the disorders of the intestinal microbiota. Compared to placebo, probiotic therapy was found to reduce pain and severe symptoms among people with the IBS, also known as the prevention of diarrhoea associated with antibiotics in children.
On the mental front, a small study involving adults who have been diagnosed with the IIBS and depression found probiotic-bifidobacteria longum that offer depression relief. In six weeks, 64% of the depression treatment package decreased compared to 32% of the control group that received placebo.
Those have that probiotic also reported symptoms less than IBS and improves the quality of life. At the end of 10 weeks, approximately double the number of the treatment package still reported low levels of depression.
Interestingly, the functional MRI scans revealed a link between reductions in the degree of depression and actual changes in brain activity, specifically in the areas concerned with mood regulation, such as amygdala. As noted by Dr. Roger McIntyre, professor of psychiatry and pharmacology at the University of Toronto, who did not participate in the study:
"We know that one part of the brain, the Amygdala, tends to be red hot in people with depression, seems to be calming with this interference. It provides more scientific credibility that something in the brain, and at a very biological level, seems to be affected by this probiotic."
Are Personalized Probiotics the Answer?
As for the probiotic strains are the best, the answer may be harder to come by. Emma Allen-Verco, a microbiological at the University of Guelph in Ontario, said the American Scientific, "bacterial strains are so genetically different from each other, and everyone has different intestinal microbiota... Perhaps there will never be one suitable for everyone probiotic."
Studies suggest, for example, that some people may benefit more from the probiotic than others if they are "low" in a given group and then added to the diet. The American Scientific reported:
"In other words, they have intestinal ecosystems and vacancies that have filled the probiotic. This is exactly the kind of insight that clinical physicians need to create and recommend more effective probiotic. If the doctor knows that an individual with severe diarrhea has a small population of certain useful microbes, for example, then the description of the lost strain should increase the chance of successful treatment."
Other research has researched the benefits of certain strains of bacteria, such as bifido-bacteria, which tend to be abundant in the babies' intestines but usually make up less than 10% of the intestinal microbiome in adults. Low levels of bifido-bacteria, in turn, are associated with chronic diseases such as digestive disorders and diabetes, sensitive asthma, even obesity, while supplementing with it has been found for the benefit of the IIBS, inflammatory bowel disease, chronic fatigue syndrome, psoriasis, depression and more.
Another type of bacteria, lactobacillus, has been shown to reduce anxiety in animal studies, while taking probiotic with eight different bacterial strains reduced aggressive and ruminates in a study of adult volunteers.
The Lectin Connection and How Leaky Gut Can Destroy Your Health
It's important to be aware that gut dysbiosis, also known as leaky gut, is not only a major gut disrupter linked to digestive disorders, but may also contribute to other chronic diseases like Alzheimer's and possibly cancer. If your gut is leaky, your blood-brain barrier is also leaky, which means toxins can go right into your brain, affecting your cognitive and mental health.
Further, leaky gut can be triggered by a number of factors, including imbalanced gut microbiota that result from dietary factors, such as the consumption of sugar as well as lectins. This latter component is very important. Lectins are plant proteins, sometimes called sticky proteins or glycan-binding proteins, because they seek out and bind to certain sugar molecules on the surface of cells. There are many types of lectins, and the main difference between them is the type of sugar each prefers and binds to.
Some — including wheat germ agglutinin (WGA), found in wheat and other grass-family seeds — bind to specific receptor sites on your intestinal mucosal cells and interfere with the absorption of nutrients across your intestinal wall.
As such, they act as "antinutrients," and can have a detrimental effect on your gut microbiome by shifting the balance of your bacterial flora — a common precursor to leaky gut. Dr. Steven Gundry, author of "The Plant Paradox: The Hidden Dangers in 'Healthy' Foods That Cause Disease and Weight Gain," makes a strong case for a lectin-free diet, stating:
"Our microbiome is, I think, our early warning system, because about 99% of all genes that make up [the human body] are actually non-human, and they are bacterial, viral and fungal... [FROM WHICH] have uploaded most of the information about interacting with our environment... Because microbiome is capable of almost instantaneous change and processing information that we actually don't have the ability to do.
We started to realize... That microbiome is not only how we interact with plant materials... Like lectins, but perhaps most importantly, our microbiome system immune whether a particular compound plant is a friend or an enemy [based on] how much time we knew that plant complex. There are lectins in everything.
But the longer we interact with lectins and the time we interact with them, the greater the small quality that tells our immune system, "Hey, guys, it's awesome." We've known these guys for 40 million years. Calm your nerves. They are pain, but we can deal with them."
From an evolutionary perspective, if you look at modern foods-they say grain and beans, which we started interacting with 10, 000 years ago, which is a twinkling of time--our microbiome [regadrs them as] external materials...There is no lectin speed dating back in evolution.
Lectins are strongly associated with autoimmune disorders of all kinds, primarily through the leaky bowel movement. They found in many of the most cherished foods, such as:
In addition, according to Gundry, glyphosate, which is not only sprinkled on the GE crops via Roundup but also used to desiccate wheat in the United States, is also very problematic, and your decimal is microbiome and the bowel leak increases. It's another reason to eat organic as much as possible.
To learn more, I highly recommend picking up a copy of "The Pant Paradox", especially if you have already cleaned up your diet and still struggle with excess weight and/or health problems. Of course, anyone who has autoimmune disorder would also be wise to take a closer look at the letcins.